6) Dehydro halogenation of alkyl halides

PHARMACEUTICAL ORGANIC CHEMISTRY

CHAPTER-6

Dehydro halogenation of alkyl halides

This chapter comes under Organic Chemistry. It deals with the following;

Dehydro halogenation of alkyl halides: 1,2 elimination, kinetics, E2 and E1 mechanism, elimination via carbocation, evidence for E2 mechanism, absence of rearrangement isotope effect, absence hydrogen exchange, the element effect, orientation and reactivity, E2 versus E1, elimination versus substitution, dehydration of alcohol, ease of dehydration, acid catalysis, reversibility, orientation.

Text books 

a. T.R.Morrison and R. Boyd - Organic chemistry, 

b. Bentley and Driver-Text book of Pharmaceutical chemistry 

c. I.L.Finer- Organic chemistry, the fundamentals of chemistry 

Reference books 

a. Organic chemistry – J.M.Cram and D.J.Cram 

b. Organic chemistry- Brown 

c. Advanced organic chemistry- Jerry March, Wiley 

d. Organic chemistry- Cram and Hammered, Pine Hendrickson 

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