5) Nuclophilic aliphatic substitution mechanism

PHARMACEUTICAL ORGANIC CHEMISTRY

CHAPTER-5

Nucleophilicophilic aliphatic substitution mechanism

This chapter comes under Organic Chemistry. It deals with the following;

Nucleophilic aliphatic substitution mechanism: Nucleophiles and leaving groups, kinetics of second and first order reaction, mechanism and kinetics of SN2 reactions. Stereochemistry and steric hindrance, role of solvents, phase transfer catalysis, mechanism and kinetics of SN1 reactions, stereochemistry, carbocation and their stability, rearrangement of carbocation, role of solvents in SN1 reaction, Ion dipole bonds, SN2 versus SN1 solvolyses, nucleophilic assistance by the solvents.

Text books 

a. T.R.Morrison and R. Boyd - Organic chemistry, 

b. Bentley and Driver-Text book of Pharmaceutical chemistry 

c. I.L.Finer- Organic chemistry, the fundamentals of chemistry 

Reference books 

a. Organic chemistry – J.M.Cram and D.J.Cram 

b. Organic chemistry- Brown 

c. Advanced organic chemistry- Jerry March, Wiley 

d. Organic chemistry- Cram and Hammered, Pine Hendrickson 

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