7) Electrophillic and free radicals addition

PHARMACEUTICAL ORGANIC CHEMISTRY

CHAPTER-7

Electrophillic and free radicals addition

This chapter comes under Organic Chemistry. It deals with the following;

Electrophillic and free radicals addition: Reactions at carbon-carbon, double bond, electrophile, hydrogenation, heat of hydrogenation and stability of alkenes, markownikoff rule, addition of hydrogen halides, addition of hydrogen bromides, peroxide effect, electrophillic addition, mechanism, rearrangement, absence of hydrogen exchange, orientation and reactivity, addition of halogen, mechanism, halohydin formation, mechanism of free radicals additon, mechanism of peroxide initiated addition of hydrogen bromide, orientation of free addition, additions of carbene to alkene, cyclo addition reactions.

Text books 

a. T.R.Morrison and R. Boyd - Organic chemistry, 

b. Bentley and Driver-Text book of Pharmaceutical chemistry 

c. I.L.Finer- Organic chemistry, the fundamentals of chemistry 

Reference books 

a. Organic chemistry – J.M.Cram and D.J.Cram 

b. Organic chemistry- Brown 

c. Advanced organic chemistry- Jerry March, Wiley 

d. Organic chemistry- Cram and Hammered, Pine Hendrickson 

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