Individualization of drug dosage regimen (Variability – Genetic, Age and Weight , disease, Interacting drugs).

CLINICAL PHARMACOKINETICS & PHARMACOTHERAPEUTIC DRUG MONITORING

UNIT-4

Therapeutic Drug monitoring: 

Individualization of drug dosage regimen (Variability – Genetic, Age and Weight , disease, Interacting drugs).

 

Get the notes below!

Dosage regimen is defined as the manner in which the drug is taken.

► For some drugs like analgesics single dose is efficient for optimal

therapeutic effect.

► The duration of most illnesses are longer than the therapeutic effect

produced by a single dose, in such cases drugs are required to be taken on

a repetitive doses over a period of time depending upon the nature of

illness.

► An optimal multiple dosage regimen is the one in which the drug is

administered in suitable doses with sufficient frequency that ensures

maintenance of plasma conc. Within the therapeutic window for entire

duration of therapy.

INDIVIDUALIZATION

► Rational drug therapy requires individualization of Dosage regimen to fit

a particular patient's needs.

► The application of Pharmacokinetic principles in the dosage regimen

design for the safe and effective management of illness in individual

patient is called as Clinical Pharmacokinetics.

► Same dose of drug may produce large differences in pharmacologic

response in different individuals; this is called as Inter-subiect variability.

► It means that the dose required to produce a certain response varies from

individual to individual.

Individualization of drug dosage regimen (Variability – Genetic, Age and Weight , disease, Interacting drugs).