Unit 2- Drug dosing in the pediatrics patients

CLINICAL PHARMACOKINETICS & PHARMACOTHERAPEUTIC DRUG MONITORING

UNIT-2

Design of dosage regimens

Drug dosing in the pediatrics patients

 

Get the notes below!

Drug dosing in the pediatrics patients

Pediatric Patients means infants, children, adolescents, and

young adults up to the age of 18.

ABSORPTION:

 The composition of intestinal fluids and the

permeability of the gut vary during childhood.

 Absorption of orally administered drugs is affected by

changes in gastric pH which decreases during infancy

to reach adult values by two years of age.

 Infants are at higher risk of toxicity via skin absorption

due to a larger surface area to volume ratio and they

also absorb more of a drug across the skin due to their

thinner stratum corneum.

 Bile secretion in the first 2–3 weeks of life is known to

be poor with luminal concentrations lower than in

adults. It is known that drug solubility increases with

bile salt concentration and therefore a difference in

concentration may have an impact on absorption in

younger patients.

Thanks to SNEHA MAVIS.