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CLINICAL PHARMACOKINETICS & PHARMACOTHERAPEUTIC DRUG MONITORING

UNIT-2

Design of dosage regimens

Drug dosing in the elderly patients

 



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Drug dosing in the elderly patients

The geriatric population is often arbitrarily
defined as patients who are older than 65 years,
and many of these people live active and healthy
lives.
 The aging process is more often associated with
physiologic changes during aging rather than
purely chronological age.
Classification of Elderly
1. Young Old (Aged 65-75 years old)
2. Old (Aged 75-85 Years old)
3. Old Old (Age >85 Years old)
 Performance capacity and the loss of homeostatic
reserve decrease with advanced age but occur to
a different degree in each organ and in each
patient.
 Decreased cognitive function in some geriatric
patients, complicated drug dosage schedules,
and/or the high cost of drug therapy may result
in poor drug compliance, lack of drug efficacy,
drug interactions, and/or drug intoxication.


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