Unit 3- Inhibition of Biliary Excretion

CLINICAL PHARMACOKINETICS & PHARMACOTHERAPEUTIC DRUG MONITORING

UNIT-3

Pharmacokinetics of Drug Interaction

Inhibition of Biliary Excretion

 

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Inhibition of Biliary Excretion

Drugs are often conjugated and excreted in bile

 Example: In humans, most water-soluble drugs and

metabolites of relatively high molecular weight are

excreted largely in bile

 This excretion is mainly via transporters and the

possibility exists for drugs interactions with concomitant

administration

 Conjugates such as glucuronides are often excreted in

bile and deconjugated in the intestinal tract and

reabsorbed by enterohepatic circulation

 Drug interactions in the process of biliary excretion may

affect the residence time and AUC of unchanged drug

plasma.

Thanks to BALA KRISHNAN.