ROBBINS AND COTRAN - Pathologic Basis of Disease

ROBBINS AND COTRAN

Pathologic Basis of Disease 

N I N T H  E D I T I O N

In the preface of the very first edition (1957), Stanley Robbins wrote: “The pathologist is interested not only in the recognition of structural alterations, but also in their significance, i.e., the effects of these changes on cellular and tissue function and ultimately the effect of these changes on the patient. It is not a discipline isolated from the living patient, but rather a basic approach to a better understanding of disease and therefore a foundation of sound clinical medicine.

” We hope we continue to illustrate the principles of pathology that Dr. Robbins enunciated with such elegance and clarity over half a century ago. This edition, like all previous ones, has been extensively revised, and some areas have been completely rewritten. A few examples of significant changes are as follows: • A feature new to this edition is the introduction of Key Concepts boxes, scattered in each chapter to summarize “take home” messages relating to major topics covered in each disease or disease group. • Chapter 2 has been updated to include novel pathways of cell death beyond the long-established pathways of necrosis and apoptosis. Indeed, the distinction between these two is being blurred. Autophagy, which has begun to take center stage in diseases ranging from aging to cancer and neurodegeneration, has been revised, as have the possible molecular mechanisms of aging. • Chapter 3 now combines the discussion of inflammation with repair, since these two processes run concurrently and share common mediators. • Chapter 5 includes a completely rewritten section on molecular diagnosis that reflects rapid advances in DNA sequencing technology. • Chapter 7 has been extensively revised to incorporate knowledge and concepts of tumor biology gleaned from deep sequencing of cancers. 

• The ongoing revolution in “genomic medicine” has provided the impetus for extensive updates of many disease entities associated with newly described germline or somatic genetic alterations. Throughout, we have taken pains to try to only emphasize the lesions that are most common and most informative in terms of disease pathogenesis. • Chapter 18, covering diseases of the liver, has been reorganized and extensively revised to include discussion of the molecular basis of hepatic fibrosis and its regression. • Chapter 27, covering diseases of nerves and muscles, also has a fresh look. The diseases are now organized anatomically, starting from neurons and going to muscles, with diseases of neuromuscular junction bridging the two. • In addition to the revision and reorganization of the text, many new photographs and schematics have been added and a large number of the older “gems” have been enhanced by digital technology.

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