9) Theory of resonance

PHARMACEUTICAL ORGANIC CHEMISTRY

CHAPTER-9

Theory of resonance

This chapter comes under Organic Chemistry. It deals with the following;

Theory of resonance: Allyl radical as a resonance hybrid, stability, orbital picture, resonance stabilisation of allyl radicals, hyper conjugation, allyl cation as a resonance hybrid, nucleophyllic substitution in allylic substrate, SN1 reactivity, allylic rearrangement, resonance stabilisation of allyl cation, hyper conjugation, nucleophilic substitution in allylic substrate, SN2 nucleophilic substituion in vinylic substrate, vinylic cation, stability of conjugated dienes, resonance in alkenes, hyper conjugation, ease of formation of conjugated dienes, orientation of elimination, electrophilic addition to conjugated dienes, 1,4- addition, 1,2-versus 1,4-addition, rate versus equilibrium, orientation and reactivity of free radical addition to conjugated dienes.

Text books 

a. T.R.Morrison and R. Boyd - Organic chemistry, 

b. Bentley and Driver-Text book of Pharmaceutical chemistry 

c. I.L.Finer- Organic chemistry, the fundamentals of chemistry 

Reference books 

a. Organic chemistry – J.M.Cram and D.J.Cram 

b. Organic chemistry- Brown 

c. Advanced organic chemistry- Jerry March, Wiley 

d. Organic chemistry- Cram and Hammered, Pine Hendrickson 

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